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张大生

中国科学院上海辰山植物科学研究中心
在岗研究生导师情况介绍


姓 名张大生
研究组观赏植物资源及创新利用研究组
性 别
专业名称分子生物学
技术职务研究员
行政职务-
Mail地址zhdash001@163.com
指导博士
生总数
0指导硕士
生总数
3通讯地址上海松江区辰花公路3888号 上海辰山植物园/中科院上海辰山植物科学研究中心
目前博士
生数
0目前硕士
生数
3邮政编码201602
研究方向观赏植物基因工程
研究工作(1)荷花花色素代谢途径功能基因研究; (2)重瓣花的发生机制; (3)荷花花粉遗传发育研究。
获奖情况上海市“明治乳业生命科学奖”
指导研究
生情况
2014-2015年在上海辰山植物园(中国科学院上海辰山植物科学研究中心)培养硕士研究生3名(均在读)。
个人简介教育:本科:江苏师范大学生命科学学院(学士,1996),研究生:福建农林大学园艺学院(硕士,2002)、上海交通大学生命科学技术学院(博士,2010)。 
经历: 江苏师范大学讲师 (1996-2005);同济大学心律失常教育部重点实验室助理研究员(2010-2013);中国科学院上海辰山植物科学研究中心副研究员,福建农林大学专硕校外指导老师(2014-至今)。
近期三年(代表性)论著1. Lijie Cui, Fenfen Huang, Dasheng Zhang, Pan Liao, Yuping Lin, Jie Zong, Guoyin Kai*. Transcriptome exploration for further understanding of the tropane alkaloids biosynthesis in Anisodus acutangulus. Molecular Genetics and Genomics, 2015, DOI: 10.1007/s00438-015-1005-y 
2. Lijie Cui, Xiaoling Ni, Qian Ji, Xiaojuan Teng, Yanrui Yang, Chao Wu, David Zekria, Dasheng Zhang, Guoyin Kai *. Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila. Scientific Reports, 2015, 5, 8227; DOI:10.1038/srep08227. 
3. Weiwei Zhang, Daike Tian, Xiu Huang, Yuxian Xu, Haibo Mo, Yanbo Liu, Jing Meng, Dasheng Zhang. Characterization of Flower-Bud Transcriptome and Development of Genic SSR Markers in Asian Lotus (Nelumbo nucifera Gaertn.), PLOS ONE, 2014, 9 (11), e112223.
4. Jun Li, Changming Li, Dasheng Zhang, et al., SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain, Nature Communication, 2014, Oct 8;5:5177. doi: 10.1038/ncomms6177. 
5. Jun Li, Man Qi, Changming Li, Dan Shi, Dasheng Zhang, et al., Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy, Cell Research, 2014, 24, 977-993,  doi:10.1038/cr.2014.94 
6. J Li, DS Zhang (Co-first Author), JC Ye, et al. Dynamin-2 mediates heart failure by modulating Ca2+-dependent cardiomyocyte apoptosis. International Journal of Cardiology, 2013, Oct 3;168(3):2109-2119. 
7. J Li, L Xu, JC Ye, X Li, DS Zhanget al. Aberrant dynamin 2-dependent Na+/H+ exchanger-1 trafficking contributes to cardiomyocyte apoptosis, Journal of Cellular and Molecular Medicine. 2013, Sep;17(9):1119-1127.   
8. Junjie Xiao, Dandan Liang, Hong Zhang, Ying Liu, Dasheng Zhanget al. MicroRNA-204 is required for differentiation of human-derived cardiomyocyte progenitor cells, Journal of Molecular and Cellular Cardiology, 2012, 53: 751–759.
9. Congmao Wang, Jie Xu, Dasheng Zhanget al; An effective approach for identification of in vivo protein–DNA binding sites from paired-end ChIP-Seq data. BMC Bioinformatics, 2010, 11: 81.
10. Jie Xu, Caiyun Yang, Zheng Yuan, Dasheng Zhanget al. Regulatory Network of ABORTED MICROSPORES (AMS) Required for Postmeiotic Male Reproductive Development in Arabidopsis thaliana. The Plant Cell, 2010, 22 (1): 91-107.
11. Dasheng Zhang, Wanqi Liang, Changsong Yin, et al; OsC6, encoding a lipid transfer protein (LTP), is required for postmeiotic anther development in rice. The Plant physiology, 2010, 154:149-162. 
12. Zhang Dasheng, Tan Hexin, and Zhang Dabing; Understanding the molecular mechanism of rice pollen development. 5th International Hybrid Rice Symposium.2008.
13.   Da-Sheng Zhang, Wan-Qi Liang, Zheng Yuan, et al; Tapetum Degeneration Retardation is Critical for Aliphatic Metabolism and Gene Regulation during Rice Pollen Development. Molecular Plant, 2008, 1 (4):599-610. 
14.   Na Li, Da-Sheng Zhang (Co-first author), Hai-Sheng Liu, et al. The Rice Tapetum Degeneration Retardation Gene Is Required for Tapetum Degradation and Anther Development, The Plant Cell, 2006, 18, 2999–3014.